' 
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.7
USERS' SCORE
Good
Based on 7 Reviews
8.7
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Vitamin B12 (as Methylcobalamin)
1,500 mcg
62500%
Top Medical Research Studies
8
Vitamin B12 improves chest pain
Pseudo-Thrombotic Microangiopathy Secondary to Vitamin B12 Deficiency.
Relevant treatment insights highlighted
We observed an intriguing case involving a patient suffering from chest pain alongside severe anemia and vitamin B12 deficiency. The patient, a 44-year-old Hispanic woman, presented with escalating non-radiating chest pain, fatigue, and shortness of breath over three weeks. Her lab results showed critical pancytopenia and macrocytosis, raising concerns about a rare condition known as pseudo-thrombotic microangiopathy (TMA), which can occur due to vitamin B12 deficiency.
Initially diagnosed with pseudo-TMA, the patient was undergoing plasmapheresis and steroid treatment. However, once she received daily injections of 1000 micrograms of parenteral vitamin B, her condition began to improve significantly, leading to a resolution of her symptoms, including the chest pain.
This case highlights the importance of considering vitamin B12 deficiency in patients presenting with hemolytic anemia and chest pain. Often misdiagnosed as other conditions, patients may receive unnecessary treatments that delay the correct intervention. It’s vital to recognize the role of sufficient vitamin B12 in addressing specific symptoms like chest pain in such contexts.
Initially diagnosed with pseudo-TMA, the patient was undergoing plasmapheresis and steroid treatment. However, once she received daily injections of 1000 micrograms of parenteral vitamin B, her condition began to improve significantly, leading to a resolution of her symptoms, including the chest pain.
This case highlights the importance of considering vitamin B12 deficiency in patients presenting with hemolytic anemia and chest pain. Often misdiagnosed as other conditions, patients may receive unnecessary treatments that delay the correct intervention. It’s vital to recognize the role of sufficient vitamin B12 in addressing specific symptoms like chest pain in such contexts.
Read More
9.5
Vitamin B12 not isolated in study
Endothelial cell dysfunction in women with cardiac syndrome X and MTHFR C677T mutation.
Significant but indirect association
We examined a group of 42 women suffering from chest pain but having normal coronary arteries, known as cardiac syndrome X. Our aim was to understand the link between a specific gene mutation (C677T) and abnormal homocysteine metabolism, a condition that may influence endothelial cell dysfunction, which has been tied to chest pain.
In our study, we identified a significant connection between the C677T mutation and elevated homocysteine levels in women with syndrome X. To further assess treatment options, we focused on a group of 10 patients who were homozygous for this mutation, and we prescribed them folic acid supplements, which is known to aid in metabolizing homocysteine. After 13 weeks, we noted remarkable improvements; levels of homocysteine dropped significantly, and measures of endothelial cell function, like flow-mediated dilation, showed improvement too.
Despite the important role of folic acid, the study does not isolate the effects of vitamin B12 alone on chest pain. While we saw positive outcomes with folic acid treatment, the isolated contribution of B12 to alleviating chest pain remains unclear. Nevertheless, our findings underscore the potential of targeting homocysteine metabolism to help women with cardiac syndrome X who harbor the C677T mutation.
In our study, we identified a significant connection between the C677T mutation and elevated homocysteine levels in women with syndrome X. To further assess treatment options, we focused on a group of 10 patients who were homozygous for this mutation, and we prescribed them folic acid supplements, which is known to aid in metabolizing homocysteine. After 13 weeks, we noted remarkable improvements; levels of homocysteine dropped significantly, and measures of endothelial cell function, like flow-mediated dilation, showed improvement too.
Despite the important role of folic acid, the study does not isolate the effects of vitamin B12 alone on chest pain. While we saw positive outcomes with folic acid treatment, the isolated contribution of B12 to alleviating chest pain remains unclear. Nevertheless, our findings underscore the potential of targeting homocysteine metabolism to help women with cardiac syndrome X who harbor the C677T mutation.
Read More
8
Effects of vitamin B12 treatment
[Two cases of pulmonary thromboembolism associated with protein C and protein S deficiency and literature review].
Addresses B12 along with B6
We explored the effects of vitamin B12 treatment in two young male patients with pulmonary thromboembolism associated with protein C and protein S deficiencies. Both patients experienced a range of symptoms including chest pain, alongside lower limb pain and visual disturbances. Their diagnosis came after imaging tests revealed deep venous thrombosis and subsequent pulmonary embolism.
In the course of treatment, we noticed that the patients exhibited poor responses to standard anticoagulant therapies. To tackle this, vitamin B6 and B12 were introduced as part of their regimen. Remarkably, upon adding vitamin B12, we observed significant improvement in the patients' symptoms, such as reduced chest pain.
These findings suggest that vitamin B12 may play a beneficial role in managing symptoms of chest pain linked to this type of thromboembolic event, particularly in patients with underlying deficiencies. It’s important we recognize congenital thrombophilia when dealing with such cases, especially in younger individuals with unexplained recurrent complications before the age of 40.
In the course of treatment, we noticed that the patients exhibited poor responses to standard anticoagulant therapies. To tackle this, vitamin B6 and B12 were introduced as part of their regimen. Remarkably, upon adding vitamin B12, we observed significant improvement in the patients' symptoms, such as reduced chest pain.
These findings suggest that vitamin B12 may play a beneficial role in managing symptoms of chest pain linked to this type of thromboembolic event, particularly in patients with underlying deficiencies. It’s important we recognize congenital thrombophilia when dealing with such cases, especially in younger individuals with unexplained recurrent complications before the age of 40.
Read More
Most Useful Reviews
9.5
Reduced pain
It worked well for my spinal cord pain related to cervical spondylosis myelopathy. I started taking one capsule of vitamin B12 daily, and within a month, my neck and shoulder pain diminished significantly. The numbness in my fingers also subsided, and the cold sensation vanished. I'm now returning to my pre-illness physical condition, but I plan to continue taking it.
Read More
9
Minimal pain
After experiencing numbness and pain in my right thigh following catheter surgery for an unruptured cerebral aneurysm, I began taking B12. After completing two bottles, the pain has nearly disappeared, and the numbness has decreased. The capsules are small, odourless, and easy to swallow. I highly recommend it for anyone with similar neurological concerns.
Read More
9.5
Pain-free
Seven months into taking vitamin B12 for severe sciatica, I noticed a remarkable reduction in pain after four months, and now it’s completely gone! The pain from my herniated disc had been debilitating for nearly two years. I always take it after meals, and its small size makes it easy to swallow. I recommend it to anyone experiencing nerve pain.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.7
- All Researches
9.5
Pernicious anemia and thromboembolism
Hyperhomocysteinemia due to pernicious anemia leading to pulmonary thromboembolism in a heterozygous mutation carrier.
Limited isolation of vitamin B12
We explored a case involving a 46-year-old woman who experienced chest pain and hemoptysis, leading to the discovery of a pulmonary thromboembolism. Upon further evaluation, we found that her homocysteine levels were high and that she had low vitamin B12 and iron levels due to pernicious anemia.
Although she was diagnosed with multiple conditions, including pernicious anemia and iron-deficiency anemia, an interesting aspect of her treatment was the supplementation with vitamin B12 along with other necessary nutrients like pyridoxine, thiamine, folic acid, and iron. At the end of the therapy, not only did her vitamin B12 and folate levels return to normal, but also her homocysteine levels and red cell volume improved.
Ultimately, repeat imaging showed that the thrombus had completely resolved, suggesting a comprehensive approach to her treatment was effective. While vitamin B12 was part of her therapy, it was combined with several other treatments. Therefore, it is challenging to isolate its specific impact on her initial chest pain.
In summary, our findings point toward vitamin B12’s potential role in addressing underlying causes of hyperhomocysteinemia, but its direct effect on chest pain remains less clear-cut given the multifaceted treatment she received.
Although she was diagnosed with multiple conditions, including pernicious anemia and iron-deficiency anemia, an interesting aspect of her treatment was the supplementation with vitamin B12 along with other necessary nutrients like pyridoxine, thiamine, folic acid, and iron. At the end of the therapy, not only did her vitamin B12 and folate levels return to normal, but also her homocysteine levels and red cell volume improved.
Ultimately, repeat imaging showed that the thrombus had completely resolved, suggesting a comprehensive approach to her treatment was effective. While vitamin B12 was part of her therapy, it was combined with several other treatments. Therefore, it is challenging to isolate its specific impact on her initial chest pain.
In summary, our findings point toward vitamin B12’s potential role in addressing underlying causes of hyperhomocysteinemia, but its direct effect on chest pain remains less clear-cut given the multifaceted treatment she received.
Read More
9.5
Vitamin B12 not isolated in study
Endothelial cell dysfunction in women with cardiac syndrome X and MTHFR C677T mutation.
Significant but indirect association
We examined a group of 42 women suffering from chest pain but having normal coronary arteries, known as cardiac syndrome X. Our aim was to understand the link between a specific gene mutation (C677T) and abnormal homocysteine metabolism, a condition that may influence endothelial cell dysfunction, which has been tied to chest pain.
In our study, we identified a significant connection between the C677T mutation and elevated homocysteine levels in women with syndrome X. To further assess treatment options, we focused on a group of 10 patients who were homozygous for this mutation, and we prescribed them folic acid supplements, which is known to aid in metabolizing homocysteine. After 13 weeks, we noted remarkable improvements; levels of homocysteine dropped significantly, and measures of endothelial cell function, like flow-mediated dilation, showed improvement too.
Despite the important role of folic acid, the study does not isolate the effects of vitamin B12 alone on chest pain. While we saw positive outcomes with folic acid treatment, the isolated contribution of B12 to alleviating chest pain remains unclear. Nevertheless, our findings underscore the potential of targeting homocysteine metabolism to help women with cardiac syndrome X who harbor the C677T mutation.
In our study, we identified a significant connection between the C677T mutation and elevated homocysteine levels in women with syndrome X. To further assess treatment options, we focused on a group of 10 patients who were homozygous for this mutation, and we prescribed them folic acid supplements, which is known to aid in metabolizing homocysteine. After 13 weeks, we noted remarkable improvements; levels of homocysteine dropped significantly, and measures of endothelial cell function, like flow-mediated dilation, showed improvement too.
Despite the important role of folic acid, the study does not isolate the effects of vitamin B12 alone on chest pain. While we saw positive outcomes with folic acid treatment, the isolated contribution of B12 to alleviating chest pain remains unclear. Nevertheless, our findings underscore the potential of targeting homocysteine metabolism to help women with cardiac syndrome X who harbor the C677T mutation.
Read More
8
Vitamin B12 improves chest pain
Pseudo-Thrombotic Microangiopathy Secondary to Vitamin B12 Deficiency.
Relevant treatment insights highlighted
We observed an intriguing case involving a patient suffering from chest pain alongside severe anemia and vitamin B12 deficiency. The patient, a 44-year-old Hispanic woman, presented with escalating non-radiating chest pain, fatigue, and shortness of breath over three weeks. Her lab results showed critical pancytopenia and macrocytosis, raising concerns about a rare condition known as pseudo-thrombotic microangiopathy (TMA), which can occur due to vitamin B12 deficiency.
Initially diagnosed with pseudo-TMA, the patient was undergoing plasmapheresis and steroid treatment. However, once she received daily injections of 1000 micrograms of parenteral vitamin B, her condition began to improve significantly, leading to a resolution of her symptoms, including the chest pain.
This case highlights the importance of considering vitamin B12 deficiency in patients presenting with hemolytic anemia and chest pain. Often misdiagnosed as other conditions, patients may receive unnecessary treatments that delay the correct intervention. It’s vital to recognize the role of sufficient vitamin B12 in addressing specific symptoms like chest pain in such contexts.
Initially diagnosed with pseudo-TMA, the patient was undergoing plasmapheresis and steroid treatment. However, once she received daily injections of 1000 micrograms of parenteral vitamin B, her condition began to improve significantly, leading to a resolution of her symptoms, including the chest pain.
This case highlights the importance of considering vitamin B12 deficiency in patients presenting with hemolytic anemia and chest pain. Often misdiagnosed as other conditions, patients may receive unnecessary treatments that delay the correct intervention. It’s vital to recognize the role of sufficient vitamin B12 in addressing specific symptoms like chest pain in such contexts.
Read More
8
Effects of vitamin B12 treatment
[Two cases of pulmonary thromboembolism associated with protein C and protein S deficiency and literature review].
Addresses B12 along with B6
We explored the effects of vitamin B12 treatment in two young male patients with pulmonary thromboembolism associated with protein C and protein S deficiencies. Both patients experienced a range of symptoms including chest pain, alongside lower limb pain and visual disturbances. Their diagnosis came after imaging tests revealed deep venous thrombosis and subsequent pulmonary embolism.
In the course of treatment, we noticed that the patients exhibited poor responses to standard anticoagulant therapies. To tackle this, vitamin B6 and B12 were introduced as part of their regimen. Remarkably, upon adding vitamin B12, we observed significant improvement in the patients' symptoms, such as reduced chest pain.
These findings suggest that vitamin B12 may play a beneficial role in managing symptoms of chest pain linked to this type of thromboembolic event, particularly in patients with underlying deficiencies. It’s important we recognize congenital thrombophilia when dealing with such cases, especially in younger individuals with unexplained recurrent complications before the age of 40.
In the course of treatment, we noticed that the patients exhibited poor responses to standard anticoagulant therapies. To tackle this, vitamin B6 and B12 were introduced as part of their regimen. Remarkably, upon adding vitamin B12, we observed significant improvement in the patients' symptoms, such as reduced chest pain.
These findings suggest that vitamin B12 may play a beneficial role in managing symptoms of chest pain linked to this type of thromboembolic event, particularly in patients with underlying deficiencies. It’s important we recognize congenital thrombophilia when dealing with such cases, especially in younger individuals with unexplained recurrent complications before the age of 40.
Read More
7
Vitamin B12's effect on angina
Hyperhomocysteinemia and methylenetetrahydrofolate reductase polymorphism in a patient with coronary artery disease and repetitive miscarriages.
Concerns on vitamin B12 benefits
We explored the case of a 53-year-old woman with stable angina, who also experienced three unexplained first-trimester miscarriages. Her health evaluations revealed moderate hyperhomocysteinemia attributed to a genetic mutation known as MTHFR C677T. This condition, along with factors like abdominal obesity and post-menopausal status, raised concerns about her cardiovascular and reproductive health.
The patient began a treatment regimen that included vitamins B6, B12, and folic acid, alongside standard angina therapy. Notably, two months into this treatment, her homocysteine levels decreased by 28.6%, and there was a reported improvement in her overall clinical condition. However, it’s important to note that while vitamin supplementation showed effectiveness in lowering homocysteine levels, current evidence doesn’t strongly support that this leads to a significant reduction in cardiovascular events.
As we consider the role of vitamin B12 in treating chest pain, we recognize the complex relationship between homocysteine levels and cardiovascular health. While the vitamin may contribute positively to certain health outcomes, its isolated effect in preventing chest pain remains unclear and needs more research.
The patient began a treatment regimen that included vitamins B6, B12, and folic acid, alongside standard angina therapy. Notably, two months into this treatment, her homocysteine levels decreased by 28.6%, and there was a reported improvement in her overall clinical condition. However, it’s important to note that while vitamin supplementation showed effectiveness in lowering homocysteine levels, current evidence doesn’t strongly support that this leads to a significant reduction in cardiovascular events.
As we consider the role of vitamin B12 in treating chest pain, we recognize the complex relationship between homocysteine levels and cardiovascular health. While the vitamin may contribute positively to certain health outcomes, its isolated effect in preventing chest pain remains unclear and needs more research.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Reduced pain
It worked well for my spinal cord pain related to cervical spondylosis myelopathy. I started taking one capsule of vitamin B12 daily, and within a month, my neck and shoulder pain diminished significantly. The numbness in my fingers also subsided, and the cold sensation vanished. I'm now returning to my pre-illness physical condition, but I plan to continue taking it.
Read More
9
Minimal pain
After experiencing numbness and pain in my right thigh following catheter surgery for an unruptured cerebral aneurysm, I began taking B12. After completing two bottles, the pain has nearly disappeared, and the numbness has decreased. The capsules are small, odourless, and easy to swallow. I highly recommend it for anyone with similar neurological concerns.
Read More
9.5
Pain-free
Seven months into taking vitamin B12 for severe sciatica, I noticed a remarkable reduction in pain after four months, and now it’s completely gone! The pain from my herniated disc had been debilitating for nearly two years. I always take it after meals, and its small size makes it easy to swallow. I recommend it to anyone experiencing nerve pain.
Read More
9.5
Back pain relief
Taking one capsule of vitamin B12 after breakfast dramatically relieved my unbearable back pain within three days. I didn’t expect such quick results but am very grateful. I also take Metgluco for diabetes, which can cause B12 deficiency, so I believe this has helped improve my back pain.
Read More
8.8
Reduced shocks
I take B12 for peripheral neuropathy and find Doctor's Best the most reliable brand. It significantly reduces the pain and 'electric shocks' caused by the condition. The quality of their supplements is consistently high, and I appreciate the convenient flip lid on the container.
Read More
